ReviewCureus2025
Voice Outcomes in Patients With Laryngopharyngeal Reflux: A Systematic Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The relationship of laryngopharyngeal reflux-related signs and symptoms to vocal complaints in professional classical singers.Croatian medical journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laryngopharyngeal reflux (LPR) commonly causes voice disturbances, yet treatment efficacy remains debated. This review synthesizes evidence on voice outcomes in patients with LPR. A Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guided systematic review (2000-2024) identified eight studies evaluating pharmacological, behavioral, and diagnostic approaches. Random-effects meta-analyses were conducted to assess effect sizes (ES), heterogeneity (I²), and subgroup differences. Behavioral interventions (e.g., Lee Silverman Voice Treatment {LSVT}, voice therapy) demonstrated robust efficacy (ES=0.60, 95% CI: 0.45-0.76, I²=0%), whereas proton pump inhibitors (PPIs) showed negligible effects (ES = -0.15). Adjunctive rikkunshito significantly improved outcomes in refractory LPR cases (ES=0.82). Diagnostic methods based on acoustic analysis or the Voice Handicap Index (VHI) yielded more reliable outcomes (ES=0.56) than those based on clinical symptoms or the Reflux Symptom Index (RSI) (ES=0.32, I²=94.45%). Long-term benefits beyond six months were inconsistent (ES=0.25, I²=97.47%). Behavioral therapies outperform pharmacological treatments in managing LPR-related voice dysfunction, though diagnostic precision and long-term adherence remain critical. Future studies should prioritize standardized diagnostic protocols and investigate multimodal therapeutic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.