ReviewFrontiers in pharmacology2025
Efficacy of platelet-rich plasma injection with percutaneous endoscopic lumbar discectomy for lumbar disc herniation: a systematic review and meta-analysis.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Robot-assisted versus fluoroscopy-guided spinal fusion for lumbar spondylolisthesis: a GRADE-assessed meta-analysis on surgical parameters, clinical outcomes, and complications.Journal of robotic surgery · 2026Pooled it
- Unilateral biportal endoscopic transforaminal lumbar interbody fusion versus minimally invasive transforaminal lumbar interbody fusion for single-level lumbar spondylolisthesis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- The efficacy and safety of endoscopic surgery combined with platelet-rich plasma for lumbar disk herniation: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Spine-Related Health Care Utilization and Costs Following Orthobiologic Injection Versus Lumbar Surgery for Degenerative Spine Conditions.medRxiv : the preprint server for health sciences · 2026Article
- Uniportal endoscopic lumbar interbody fusion versus minimally invasive transforaminal lumbar interbody fusion for the treatment of lumbar degenerative diseases: a systematic review and meta-analysis.European journal of medical research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Our aim was to compare the efficacy of percutaneous endoscopic lumbar discectomy (PELD) with or without platelet-rich plasma (PRP) injections for the treatment of lumbar disc herniation (LDH). Methods: Literature was searched in six databases from inception to 2 May 2025. Meta-analysis was performed using stata17 software. Results: Eight studies were included, comprising a total of 717 patients (349 in the treatment group and 368 in the control group). At the final follow-up, the treatment group significantly provided lower visual analogue scale, intervertebral disc protrusion, recurrence rates, Oswestry disability index and higher intervertebral disc height, Japanese Orthopaedic Association scores, spinal canal cross-sectional area and ratio value of disc grey scale, compared to the control group ( Conclusion: Our findings indicate that for the treatment of LDH, PELD combined with PRP injection markedly enhances clinical efficacy while reducing recurrence rates compared to PELD alone. Moving forward, larger multicenter randomized controlled trials with extended follow-up periods are necessary to confirm the long-term efficacy and safety of this combination therapy. Systematic Review Registration: Identifier CRD420251044871.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.