Evidence map›Paper›PMID 40969908›Full record

ArticleFood science & nutrition2025

The Causal Relationship Between Multiple Modifiable Risk Factors and Hallux Valgus: A Two-Sample Mendelian Randomization Study.

Siyi Liu, Wanqin Zheng, Haitao Chen, Ming Tu, Yongkang Zhong, Yihan Lou, Yinxian Wen, Liaobin Chen

Abstract read
In one paragraph

Article in Food science & nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Factors Related to the Etiology of Hallux Abducto Valgus: A Systematic Review.Journal of functional morphology and kinesiology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Siyi LiuDivision of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Wuhan China.
Wanqin ZhengDivision of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Wuhan China.
Haitao ChenDivision of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Wuhan China.
Ming TuDivision of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Wuhan China.
Yongkang ZhongDivision of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Wuhan China.
Yihan LouDivision of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Wuhan China.
Yinxian WenDivision of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Wuhan China.
Liaobin ChenDivision of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery Zhongnan Hospital of Wuhan University Wuhan China.ORCID https://orcid.org/0000-0002-8778-1457

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This Mendelian randomization (MR) study aimed to investigate the potential causal associations between modifiable lifestyle/metabolic factors and the risk of hallux valgus (HV), a common foot deformity characterized by lateral deviation of the great toe. We selected independent genetic variants strongly associated with five lifestyle factors (lifetime smoking index, smoking initiation, alcohol consumption, coffee intake, and vigorous physical activity) and ten metabolic traits (body mass index (BMI), waist-hip ratio, type 2 diabetes, systolic/diastolic blood pressure, high/low-density lipoprotein, apolipoprotein A-1/B, and triglycerides) as instrumental variables through rigorous quality control (

Indexed as

hallux valguslifestyleMendelian randomization studymetabolic factorrisk factors

Identifiers

PMID40969908
PMCPMC12441740

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.