ArticleACS pharmacology & translational science2025
A Difluorinated Derivative of ARC-111 Suppresses Intrahepatic Cholangiocarcinoma Growth via Targeting Topoisomerase I.
Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Intrahepatic cholangiocarcinoma (ICC) has limited treatment options and a poor prognosis. Thus, novel therapeutics are urgently needed. Topoisomerase I (Top I), an essential DNA regulatory enzyme, is commonly upregulated in malignancies and contributes to their aggressive growth. ARC-111 derivative
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