ArticleACS pharmacology & translational science2025
Cross-Species Extrapolation of Neonatal Fc Receptor (FcRn) Binding Affinity to Predict Monoclonal Antibody Pharmacokinetics in Humans Using Physiologically Based Pharmacokinetic Modeling (PBPK): Are We There Yet?
Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Data-intensive immune network modelling for One Health.Briefings in bioinformatics · 2026Review
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Authors and funding
6 authors.
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Abstract
Physiologically based pharmacokinetic (PBPK) modeling is a useful tool during drug development due to its ability to extrapolate pharmacokinetics (PK) between species and populations. For monoclonal antibodies (mAbs), these models can be used to support dose selection, especially for first-in-human (FIH) trials. In the PBPK model for biologics in the software PK-Sim, salvaging from endosomal degradation via the neonatal fragment crystallizable receptor (FcRn) is a critical process for the systemic clearance of mAbs. However, high variability is associated with in vitro measurements of the dissociation constant (
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