ArticleACS pharmacology & translational science2025
DNA to RNA Tuning of a Pyrrolidine-Derived Quinoxaline Scaffold: Magnesium Induces Binding and Inhibition of Internal Ribosomal Entry Site RNA-Mediated Translational of Hepatitis C Virus.
Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Selective targeting of disease-relevant RNA with small molecules remains challenging due to the dynamic conformation of RNA and the nonspecific binding of ligands toward DNA. The internal ribosome entry site (IRES) RNA of the hepatitis C virus (HCV) is a critical antiviral drug target for structure-specific therapeutics. Small molecule inhibitors capable of altering the Mg
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