Evidence map›Paper›PMID 40969871›Full record

ArticleACS pharmacology & translational science2025

Next-Generation Lipid Prodrugs Orally Deliver Tenofovir via Enhanced Chylomicron Incorporation.

Hannah Beth Gold, Nicole Pribut, Esther L Outtrim, Priscilla Davidson, Christopher M Monaco, August Myers, Carrie Qi Sun, Goknil Pelin Coskun, Andrea Mancia, Yanli Yang and 8 more

Abstract read
In one paragraph

Article in ACS pharmacology & translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hannah Beth GoldDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.
Nicole PributDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0003-0439-9162
Esther L OuttrimDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.
Priscilla DavidsonDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.
Christopher M MonacoDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0001-7802-6188
August MyersDepartment of Laboratory Medicine & Pathology, University of Washington School of Medicine, Seattle, Washington 98195, United States.
Carrie Qi SunDepartment of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Goknil Pelin CoskunDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.
Andrea ManciaDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.
Yanli YangDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.
Samantha BurtonDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.
Areeb AftabDepartment of Laboratory Medicine & Pathology, University of Washington School of Medicine, Seattle, Washington 98195, United States.
Cindy A DerdeynDepartment of Laboratory Medicine & Pathology, University of Washington School of Medicine, Seattle, Washington 98195, United States.
Rebecca S ArnoldDepartment of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
John A PetrosDepartment of Urology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Ken LiuDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.
Eric J MillerDepartment of Pharmacology & Chemical Biology, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0003-3659-0105
Dennis C LiottaDepartment of Chemistry, Emory University College of Arts & Sciences, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0002-7736-7113

Funding

Atlanta Clinical and Translational Science Institute (ACTSI) RenewalUL1TR000454 · NCATS · EMORY UNIVERSITY · PI STEPHENS, DAVID S · 2012 to 2016
$25.8M
Using DNA/MVA/protein immunization of rhesus macaques to investigate how the background of the HIV-1 envelope and nature of the protein boost shape the genetic and functional antibody landscape.R01AI128837 · NIAID · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD, DERDEYN, CYNTHIA ANN · 2017 to 2021
$5.9M
Tracking the evolutionary trajectory of neutralizing antibodies following BG505 SOSIP immunizationR01AI174979 · NIAID · UNIVERSITY OF WASHINGTON · PI DERDEYN, CYNTHIA ANN · 2023 to 2025
$3.9M
Graduate Training in the Pharmacological SciencesT32GM145445 · NIGMS · EMORY UNIVERSITY · PI Randy A. Hall · 2023 to 2026
$1.7M
FEI Transmission Electron Microscope with Tomography CapabilityS10RR025679 · NCRR · EMORY UNIVERSITY · PI SPEARMAN, PAUL W. · 2009 to 2009
$500k
NCATS NIH HHS UL1 TR000454NCRR NIH HHS S10 RR025679NIAID NIH HHS R01 AI128837NIAID NIH HHS R01 AI174979NIGMS NIH HHS T32 GM145445
6 · The paper itself

Abstract

Lipid-derived prodrugs can enhance the oral bioavailability of therapeutic agents by promoting uptake into the lymphatic system. Chylomicrons (CMs) are lipoproteins that transport dietary lipids into the lymphatics. However, their role in the systemic distribution of orally administered lipid prodrugs remains understudied. We developed an

Indexed as

absorptionchylomicronsdistributionHIVlipidslipoproteinslymphatic systemprodrugstenofovir

Identifiers

PMID40969871
PMCPMC12441861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.