ArticleJournal of diabetes and metabolic disorders2025
Risk factors and mortality associated with severe spontaneous hypoglycemia in hospitalized patients: a retrospective cohort study.
Article in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Severe spontaneous hypoglycemia (SSH) is a rare but high-risk condition in hospitalized patients, particularly among the critically ill. It is associated with increased mortality and may serve as a marker of disease severity. Objective: To describe in-hospital mortality and clinical profile observed in patients with SSH. Methods: A retrospective cohort study was conducted at Santa Izabel Hospital from November 1, 2023, to March 31, 2024. Among 5,803 hospitalized patients, 134 (2.3%) had severe hypoglycemia (≤ 40 mg/dL). After excluding insulin users and measurement errors, 47 patients (0.81%) were analyzed. Data included demographics, comorbidities, hypoglycemia recurrence, and hospital outcomes. Results: SSH prevalence was 0.81% ( Conclusion: SSH is rare but patients who experience it have elevated in-hospital mortality. It is often present in the context of rapid clinical deterioration, with many deaths in this cohort occurring within 24 h of the first episode. SSH may be a key marker of disease severity and can be further explored as a prognostic marker to guide management.
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