Evidence map›Paper›PMID 40969788›Full record

ArticleFrontiers in medicine2025

Persistent adrenocortical insufficiency before and after treatment of lymphoma with marked adrenal enlargement - a case series.

Yuri Takiyama, Takashi Nanbu, Tasuku Sato, Fumika Maruyama, Yuki Shukuda, Takao Takiyama, Chihiro Sumi, Takeshi Saito, Hiroya Kitsunai, Shuichiro Takahashi and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Yuri TakiyamaDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Takashi NanbuDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Tasuku SatoDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Fumika MaruyamaDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Yuki ShukudaDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Takao TakiyamaDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Chihiro SumiDivision of Hematology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Takeshi SaitoDivision of Hematology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Hiroya KitsunaiDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Shuichiro TakahashiDivision of Hematology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Yumi TakiyamaDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
Hiroshi NomotoDivision of Endocrinology, Metabolism, and Rheumatology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although lymphoma involving the adrenal gland is uncommon, it is associated with a high incidence of adrenal insufficiency, which may lead to adrenal crisis. The changes in adrenocortical function over the course of lymphoma treatment are not well described. We report three cases with lymphoma with bilateral adrenal enlargement who presented with adrenal insufficiency and had their adrenocortical function monitored during treatment. Case 1 was a 72-year-old man who presented with non-specific symptoms and was diagnosed with lymphoma involving the adrenal glands. Case 2 was a 71-year-old woman who was diagnosed with adrenal lesion of intravascular large B-cell lymphoma. Case 3 was an 84-year-old man diagnosed with primary adrenal lymphoma, presenting rapidly progressing bilateral adrenal tumors. All three were diagnosed with adrenal insufficiency at presentation. Rapid ACTH stimulation test was performed before and after chemotherapy and/or glucocorticoid replacement therapy, and adrenal insufficiency remained in all. Therefore, each required persistent glucocorticoid supplementation despite marked reduction in adrenal lesion. It is important to evaluate adrenocortical function and consider continuing glucocorticoid replacement therapy even after a significant treatment response in adrenal lymphomas.

Indexed as

adrenal insufficiencybilateral adrenal tumorchemotherapyglucocorticoid replacement therapylymphoma

Identifiers

PMID40969788
PMCPMC12440856

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