Evidence map›Paper›PMID 40969732›Full record

ArticleJournal of clinical medicine research2025

Telomere Length in Young Patients: Relationship With Metabolic Syndrome and Its Components.

Anna Bragina, Aida Tarzimanova, Natalia Druzhinina, Lubov Vasileva, Kirill Novikov, Irakli Loriya, Oksana Avdeenko, Yana Samohlib, Natalia Vlasova, Elizaveta Savina and 2 more

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In one paragraph

Article in Journal of clinical medicine research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna BraginaDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0002-2699-1610
Aida TarzimanovaDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0001-9536-8307
Natalia DruzhininaDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0001-8397-0210
Lubov VasilevaDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0001-5730-7837
Kirill NovikovDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0009-0007-3273-4980
Irakli LoriyaDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0001-8908-7381
Oksana AvdeenkoDepartment of Therapeutic Dentistry, Institute of Dentistry named after E.V. Borovsky, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0002-9806-6213
Yana SamohlibDepartment of Therapeutic Dentistry, Institute of Dentistry named after E.V. Borovsky, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0001-5330-5092
Natalia VlasovaDepartment of Therapeutic Dentistry, Institute of Dentistry named after E.V. Borovsky, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0003-3665-1916
Elizaveta SavinaDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0009-0003-3564-886X
Polina MakarenkoDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0003-2215-9795
Valery PodzolkovDepartment of Internal Medicine No. 2, Institute of Clinical Medicine, Sechenov First Moscow State Medical University, 19991 Moscow, Russia.ORCID https://orcid.org/0000-0002-0758-5609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous studies have reported inconsistent findings on the relationship between telomere length and metabolic syndrome (MS). The aim of the work was to study leukocyte telomere length in young patients without cardiovascular diseases and its relationship with MS and its components. Methods: This study included 450 Caucasian patients with a median age of 30 (21 - 42) years. Glycemic parameters and lipid profile components were determined using the CardioChek PA (USA, 2017). Integral metabolic indices were calculated in all patients. To investigate leukocyte telomere length, 45 were randomly selected from the total cohort of 450 participants. Results: The selected patients were divided into two groups according to the presence of MS. The median telomere length in MS patients (7.36 (6.96 - 8.67) pn) was significantly lower than in the comparison group (8.72 (8.37 - 8.96) pn) (P = 0.016). Correlation analysis was performed to assess the relationship between telomere length and various traditional cardiovascular risk factors (sex, age, smoking, and blood pressure levels), MS components, and integral metabolic indices. Several linear regression analysis models were constructed to assess the independent associations between various factors and telomere length. Age, smoking, neck circumference, triglycerides, high-density lipoprotein levels, LAP index, and the presence of dyslipidemia were significantly associated with telomere length. Conclusion: Our results are consistent with the notion of shorter leukocyte telomere length in individuals with MS and support an association with dyslipidemia in premature shortening of telomere length. The causal relationship between these changes requires further study.

Indexed as

DyslipidemiaHyperglycemiaMetabolic parametersMetabolic syndromeObesityTelomere

Identifiers

PMID40969732
PMCPMC12442315

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.