ArticleQatar medical journal2025
Intravenous lidocaine reduces pain intensity and attenuates the increase in plasma norepinephrine levels after hysterectomy.
Article in Qatar medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Intravenous lidocaine is used to treat acute postoperative pain by reducing discomfort, accelerating mobilization, and shortening hospitalization. This study evaluated the effects of intravenous bolus and continuous lidocaine infusion on pain intensity, fentanyl requirements, and plasma norepinephrine levels in hysterectomy surgery under spinal anesthesia. Methods: A double-blinded randomized clinical trial was conducted on 46 patients undergoing hysterectomy with spinal anesthesia. The lidocaine group ( Results: Statistically significant differences in resting pain NRS were observed at the 4th, 6th, 12th, and 24th hours (0.52 ± 0.51 vs. 1.52 ± 0.51, 0.61 ± 0.58 vs. 1.52 ± 0.51, 0.52 ± 0.51 vs. 1.74 ± 0.81, and 0.52 ± 0.51 vs. 1.52 ± 0.51, respectively; Conclusion: Intravenous bolus and continuous lidocaine infusion reduced postoperative pain intensity, fentanyl requirements, and norepinephrine levels without significant side effects.
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