ArticleInfection and drug resistance2025
Single-Cell Multi-Omics Deciphers Core Gene Networks and Immune Interaction Collapse in Sepsis-Associated T Cell Dysfunction.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Mechanisms of T cell activation: Integrating signaling pathways, experimental models, and therapeutic implications.EXCLI journal · 2026Review
- Protective Gene Signatures in the Transition from SIRS to Sepsis: Insights from Integrative Transcriptomics and Validation Across Clinical Cohorts.Infection and drug resistance · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Sepsis is a life-threatening condition characterized by immune dysregulation, yet the mechanisms underlying T cell dysfunction remain poorly understood. Methods: We integrated multi-omics data from public GEO datasets and prospective cohorts. Single-cell transcriptomic analysis was applied to identify core genes, followed by diagnostic and prognostic validation. Cell-cell interaction networks were constructed to investigate signaling alterations, and cross-platform validation was conducted. Results: Seven core genes ( Conclusion: Our findings highlight novel biomarkers and potential therapeutic targets for sepsis immunotherapy by systematically deciphering core gene networks and immune interaction collapse in T cell dysfunction.
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Registered trials
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