ReviewInternational journal of nanomedicine2025
The New Approach to Treating Erectile Dysfunction: Stem Cell-Derived Extracellular Vesicles.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Etiology-oriented rodent models of erectile dysfunction: a narrative review of categorization, modeling strategies, and translational applications.Translational andrology and urology · 2026Review
- Erectile dysfunction and Peyronie's disease: from biologics to nanomedicine-enabled therapies.Sexual medicine · 2026Review
- From fibrosis to restoration: the multimodal 3 Ts protocol for Peyronie's disease.International journal of impotence research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Erectile dysfunction refers to the inability of men to achieve or maintain sufficient erection during sexual activity, which significantly impacts their quality of life and mental health. The causes of erectile dysfunction are complex, involving multiple systems such as vascular, neural, endocrine, and psychological factors. Current treatment methods for erectile dysfunction have significant limitations in addressing organic lesions, particularly penile fibrosis and hypoxic microenvironments. However, the latest stem cell-derived nanovesicle technology has been found to significantly reverse cellular fibrosis and alter the cellular microenvironment, potentially offering a new therapeutic approach for erectile dysfunction. Additionally, extracellular vesicles derived from stem cells can exert stem cell-like regenerative effects while overcoming challenges associated with cell therapy, making them excellent tools for regenerative repair. Therefore, this paper summarizes the potential of extracellular vesicles from different stem cell sources in the treatment of erectile dysfunction and analyzes their engineered preclinical studies to facilitate their translation from the laboratory to clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.