ArticleNPJ dementia2025
Identifying obesity and dementia risk: body adiposity and neural connectivity in cognitively normal, mid-life adults.
Article in NPJ dementia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-Analysis of Semaglutide Effects on Adipose Tissue and Emerging Effects on Brain and Cognition.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- Fructose Intake Is Associated with Brain Metabolic Reprogramming and Exacerbation of Alzheimer-like Alterations in APP/PS1 Mice.International journal of molecular sciences · 2026Article
- Association of triglyceride-glucose index (TyG) and a body shape index (ABSI) with cognitive decline and dementia risk.PloS one · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Obesity is a risk factor for dementia, creating a chronic inflammatory state that results in white matter (WM) injury. Edge density imaging (EDI) is a novel technique that has demonstrated reliability in quantifying WM changes. Thirty obese and 20 non-obese cognitively normal adults underwent structural and diffusion-weighted magnetic resonance imaging. Visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were quantified via VOXel Analysis Suite by separating signal intensities of adipose and non-adipose tissue. Scans were processed by a pipeline (MaPPeRTrac) to generate EDI. Among obese participants, there was a negative association between the VAT/SAT ratio and EDI, which was not seen among non-obese participants. Additionally, males had decreased EDI compared to females. The results of this study suggest that obesity, through WM damage, may confer increased risk of dementia, with sex as a potential differential factor. EDI demonstrates promise in delineating the neuropathology of obesity and dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.