Evidence map›Paper›PMID 40969624›Full record

ArticleFrontiers in public health2025

Self-testing for 5 respiratory viruses in adult VACCELERATE volunteers in Germany-a pilot study on multi-pathogen rapid antigen testing to monitor community-acquired acute respiratory infections.

Julia A Nacov, Jon Salmanton-García, Sarah Grimm, Fiona A Stewart, Louise M Cremer, Lisa Marie Rochel, Erik Müller, Carolin Joisten, Christina Többen, Ben Mechtel and 7 more

Abstract read
In one paragraph

Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Julia A NacovFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Jon Salmanton-GarcíaFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Sarah GrimmFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Fiona A StewartFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Louise M CremerFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Lisa Marie RochelFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Erik MüllerFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Carolin JoistenFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Christina TöbbenFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Ben MechtelFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Julian FleigFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Ullrich BetheFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Sibylle C MellinghoffFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Zoi D PanaFaculty of Medicine and University Hospital Cologne, Clinical Trials Centre Cologne (ZKS Köln), University of Cologne, Cologne, Germany.
Heinz-Josef SchmittFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Oliver A CornelyFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Jannik StemlerFaculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute respiratory infections (ARI) are the most common human infections. Diagnostic testing for respiratory pathogens is largely restricted to medical institutions. Self-testing may allow for real-time epidemiological monitoring of ARI pathogens, in particular in individuals not seeking medical attention. Methods: Adults from the VACCELERATE Volunteer Registry received a test-kit for multiple respiratory antigens, a laminar flow device (LFD) detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza viruses A and B, respiratory syncytial virus (RSV) and adenovirus (ADV) from a single nasal swab. During one winter season, participants self-tested upon ARI symptoms, reported LFD result as well as symptoms, vaccination history, and any underlying conditions. Participants who remained without ARI symptoms self-tested on the last day of the study period. Results: Between December 7, 2022, and June 2, 2023, 1,429 participants communicated their self-testing results. Of these 1,119 (78.3%) individuals had developed ARI symptoms and self-tested until May 31, 2023. Overall, 359 of 1,119 (32.1%) tests were positive with 17 (1.5%) co-detections, resulting in 377 detected pathogens overall. Thirteen tests (1.2%) were invalid or failed technically, and 747 (66.8%) were negative. The most frequently detected pathogen was SARS-CoV-2 ( Conclusion: This study allowed real-time reporting of five endemic ARI pathogens in a citizen science project. Symptom burden was highest in influenza A. Seasonal and off-seasonal RSV detection hint toward relevant RSV circulation in adults all year round.

Indexed as

Antigens, ViralCommunity-Acquired InfectionsRespiratory Tract InfectionsSelf-TestingAdultAgedCOVID-19FemaleGermanyHumansInfluenza A virusMaleMiddle AgedPilot ProjectsSARS-CoV-2VolunteersAntigens, ViralADVincidenceinfluenzapoint prevalenceRSVSARS-CoV-2surveillance

Identifiers

PMID40969624
PMCPMC12440861

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.