Evidence map›Paper›PMID 40969595›Full record

ReviewFrontiers in nutrition2025

Role of lactoferrin in osteopenia and osteoporosis.

Deming Li, Maofeng Gao, Meng Li, Huan Zhao, Xichao Zhou, Qiaoli Gu, Huilin Yang, Qin Shi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deming Li *Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Maofeng Gao *Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Meng LiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Huan ZhaoDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Xichao ZhouDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Qiaoli GuDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Huilin YangDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Qin ShiDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute of Soochow University, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteopenia and osteoporosis (OP) are serious public health concerns that impose substantial health and economic burdens on the global population. Lactoferrin (Lf) is a natural iron-binding glycoprotein that exhibits numerous biological functions. This review summarized the role of circulating Lf and related biomarkers in maintaining bone health. Lf may protect against OP through various mechanisms, including the osteoprotegerin/receptor activator of nuclear factor κB ligand/receptor activator of nuclear factor κB, bone morphogenetic protein signaling pathway, liver-bone axis, insulin-like growth factor 1 signaling pathway, autophagy, and gut microbiota. Moreover, the peptides derived from Lf and Lf-based nanoformulations or biomaterials show potential in preventing OP. Overall, this review supports the potential application of Lf for OP.

Indexed as

bone metabolismlactoferrinmechanismsosteopeniaosteoporosis

Identifiers

PMID40969595
PMCPMC12440965

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.