ArticleFrontiers in nutrition2025
Association between blood cobalt ion concentrations and anemia and cardiovascular diseases: novel evidence of toxicity resulting from metal implants.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Sonodynamic CoMg-Quercetin Nanozyme for Antibacterial Therapy and Multifunctional Bone Regeneration in Infectious Bone Defects.Biomaterials research · 2026Article
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6 authors.
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Abstract
Background: Cobalt ions released from metal objects pose potential systemic toxicity risks, yet comprehensive epidemiological evidence linking blood cobalt ion concentrations with anemia and cardiovascular disease (CVD) remains limited. This study aims to investigate these associations and explore exposure thresholds. Methods: We utilized data from the National Health and Nutrition Examination Survey from 2015 to 2018. Outcomes included anemia, angina pectoris, arrhythmia, heart attack, heart failure, myocardial infarction, and stroke. We first used multivariate linear regression to demonstrate that metal implants are associated with elevated blood cobalt ion concentrations. Afterward, multivariable logistic regression, restricted cubic splines, and threshold effect analyses were applied to evaluate dose-response relationships between cobalt ion concentrations and disease. Results: Participants with metal implants exhibited 0.42 nmol/L higher blood cobalt concentrations than those without (95% confidence interval [CI]: 0.33-0.51). Each 1 nmol/L increase in cobalt was associated with a 36% higher anemia risk (adjusted odds ratio [OR]: 1.36, 95% CI: 1.31-1.41). Non-linear relationships were observed for CVD (inflection point: 3.94 nmol/L), with cobalt ion concentrations below this threshold showing stronger associations (OR: 1.27, 95% CI: 1.12-1.45). Cobalt exposure increased the risks of angina pectoris, arrhythmia, heart attack, heart failure, and stroke (all Conclusion: Metal object-derived cobalt exposure demonstrates significant dose-dependent associations with anemia and multiple CVD subtypes. These findings underscore the systemic toxicity of cobalt ions and advocate for enhanced clinical surveillance of blood cobalt levels in patients with metal implants.
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