ArticleSmart medicine2025
Antibacterial and Proangiogenic Hydrogel Microneedle Patches for Wound Healing.
Article in Smart medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Artificial intelligence-guided nanozyme engineering for chronic wound healing: from rational design to precision therapeutics.Bioactive materials · 2027Review
- Hierarchical Cascade-Activated Microneedle Patches for Photothermal and Chemotherapy.Smart medicine · 2026Article
- Bionic intelligent responsive barbed microneedles synergistically remodel the microenvironment for the treatment of refractory pigmentation disorders (melasma).Materials today. Bio · 2026Article
- Microneedle-based platforms for wound healing: recent advances.Journal of materials chemistry. B · 2026Review
- Machine Learning-Guided Near-Infrared Laser Processing for Precise Geometry Control in Microneedles with Downstream microLED-Triggered Photothermal Functionality.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Breaking the vicious cycle of diabetic wounds with an exosome-engineered dual-responsive microneedle patch.Materials today. Bio · 2026Article
- In-situ RhoA editing via heparinylated LNP-microsphere system for rheumatoid arthritis treatment.Journal of nanobiotechnology · 2026Article
- Microneedle-Assisted Cell Delivery and Therapy.Research (Washington, D.C.) · 2026Review
- Microneedle-guided monitoring and therapy in chronic limb-threatening ischemia.Frontiers in cell and developmental biology · 2026Review
- Chitosan-Based Wound Dressings: Property Modulation, Fabrication Strategies, and Emerging Applications in Tissue Regeneration.International journal of nanomedicine · 2026Review
- Antibacterial and Proangiogenic Hydrogel Microneedle Patches for Wound Healing.Smart medicine · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wounds represent a global and challenging healthcare issue, resulting in a cascade of consequences. Despite the widespread application of existing wound dressings, their performance and efficacy are significantly limited in terms of biocompatible matrices and functionalization for promoting vascularization and antimicrobial activity. In this study, we propose a drug-loaded microneedle based on a copolymer hydrogel composed of methacrylated chitosan and polyethylene glycol diacrylate incorporating antimicrobial peptide and vascular endothelial growth factor. These microneedles were applied to wounds where their degradation facilitated the release of the loaded drugs to exert antibacterial and angiogenic effects. In vitro experiments demonstrated that our microneedles exhibit uniform morphology, good structural integrity, controlled drug release, and other excellent properties. Upon interaction with cells and bacteria, they displayed biocompatibility and superior dual antibacterial capabilities. In an in vivo infectious wound model, the microneedles significantly promoted wound healing through their antibacterial and angiogenic effects, showing clear advantages over the control group. Thus, these drug-loaded microneedles serve as a multifunctional dressing, offering a promising novel strategy for wound repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.