ArticleNature physics2024
Survival dynamics of starving bacteria are determined by ion homeostasis that maintains plasmolysis.
Article in Nature physics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Genome-wide fitness profiling reveals flagellar rotation as an energetic liability during anaerobic maintenance inbioRxiv : the preprint server for biology · 2026Article
- ICP1 bacteriophage treatment antagonizes colonization of the zebrafish larval intestine byMicrobiology spectrum · 2026Article
- Limits of bacterial osmoadaptation during planktonic and biofilm growth: a step toward effective biofouling control.Applied and environmental microbiology · 2026Article
- Matters of life and death in computational cell biology.NPJ systems biology and applications · 2026Review
- Optimal Preservation Method for Long-term Preservation in ddHMicrobial ecology · 2026Article
- Tmn blocks phage spread via plasmolysis and triggers synergistic defence responses.bioRxiv : the preprint server for biology · 2026Article
- Discreteness, Computation, and Rules of Life for Self-Organization Dynamics Beyond Equilibrium.Newton ((New York, N.Y.) · 2026Article
- Hypoosmolarity inhibits ammonia oxidation by terrestrial and freshwater Nitrosopumilaceae members.The ISME journal · 2026Article
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- Antimicrobial peptide LL37 is potent against non-growingmSphere · 2025Article
- Mechanistic study of a low-power bacterial maintenance state using high-throughput electrochemistry.Cell · 2024Article
- Evolution and stability of complex microbial communities driven by trade-offs.Molecular systems biology · 2024Review
- Analysis of proteome adaptation reveals a key role of the bacterial envelope in starvation survival.Molecular systems biology · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The ability to survive starvation is an integral part of bacterial fitness and determines composition, turnover and biodiversity in microbial ecosystems. Starving bacteria enter a state known as plasmolysis in which their cytoplasm contracts from the cell wall. Plasmolysis is often thought to be a pathological, passive condition, arising automatically from the lack of ATP. Here we show that contrary to this notion, maintaining plasmolysis is an active, ATP-consuming state that is essential for starvation survival. We show that ion homeostasis to maintain plasmolysis consumes the largest part of the energy budget of starving cells and directly determines death rates in starvation. Our mathematical model accurately predicts death rates for various starvation conditions and perturbations. This enabled the development of an optimized starvation medium that would be ideally suited for preserving and transplanting natural microbial communities by maintaining viability but preventing outgrowth of a subset of the species.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.