ReviewFrontiers in microbiology2025
The role and mechanism of bacterial outer membrane vesicles in the development of periodontitis.
Review in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Role of bacterial outer membrane vesicles in immune evasion during infection.Archives of microbiology · 2026Review
- Bacterial Extracellular Vesicles at the Crossroads of Immune Regulation and Biofilm Dynamics: Biogenesis, Comparative Analysis, and Translational Challenges.Biomolecules · 2026Review
- Biomimetic Cell Membrane-Based Drug Delivery Systems for Oral Diseases: Engineering Strategies, Targeting Mechanisms, and Translational Challenges.Pharmaceutics · 2026Review
- Bacterial Membrane Vesicles: Biogenesis, Functions, and Emerging Biotechnological Applications.Microorganisms · 2026Review
- Bacterial outer membrane vesicles as intrinsically immunogenic and highly modifiable nanocarriers for precision tumor therapy.Molecular biology reports · 2026Review
- The role of extracellular vesicles in intercellular communication within the oral cavity.Journal of oral microbiology · 2026Review
- Gut microbiota-immune crosstalk in osteoarthritis: pathogenic mechanisms and emerging therapeutic opportunities.Frontiers in microbiology · 2026Review
- Tregs and persistentFrontiers in oral health · 2026Article
- Review
- Deciphering macrophage molecular responses toFrontiers in microbiology · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Outer membrane vesicles (OMVs), nanoscale structures actively secreted by Gram-negative bacteria, have emerged as critical pathogenic components in periodontitis. While periodontitis has traditionally been associated with biofilm accumulation and bacterial colonization, recent studies highlight that OMVs contribute to disease progression independently of whole-cell bacterial presence. These vesicles are enriched with bioactive cargo such as lipopolysaccharides (LPS), proteases, DNA, and toxins, enabling them to persist in the periodontal microenvironment and interact with host immune and structural cells. They are also actively involved in biofilm formation and contribute to the development of antimicrobial resistance. Despite growing recognition of their involvement in periodontal disease, the extent of OMV interactions with host tissues and polymicrobial communities remains unclear. This review outlines the mechanisms through which OMVs influence inflammation, immune evasion, biofilm stability, and antibiotic resistance in periodontitis. It also highlights current knowledge gaps and concludes with potential therapeutic strategies targeting OMVs for the treatment of periodontitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.