ArticleFrontiers in microbiology2025
Functional constipation in Chinese infants: disruptions in gut microbiota and urinary metabolome revealed by a cross-sectional analysis.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Gut microbiome and urinary metabolomic alterations in Chinese infants with functional constipation and yin-deficiency constitution.Frontiers in microbiology · 2026Article
- The role of theFrontiers in microbiology · 2026Review
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10 authors.
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Abstract
Background: Functional constipation (FC) is regarded as the most prevalent functional gastrointestinal disorder among children and is closely related to the intestinal microbiota. Nevertheless, there is a paucity of data regarding this relationship in Chinese infants. Methods: In this study, we investigated the alterations in gut microbiota of 79 FC infants under 2 years of age in China, using 31 balanced non-constipated (BC) children as controls. Some clinical parameters were evaluated, fecal microbiota was analyzed using 16S rRNA gene sequencing, and urinary metabolites were profiled via UPLC-Q-TOF/MS method. Results: Children with FC demonstrated significantly lower stool scale scores compared to BC group. Significant differences were observed in both microbial community composition and metabolite profiles between the FC and BC groups. The characteristic microbiota of the FC group included Conclusion: This study offers new insights into the gut microbiota and metabolomic profiles associated with FC in young children, particularly that glutathione metabolism may be a new pathway for infant constipation, underscoring the potential for developing innovative therapeutic strategies through the integration of multi-omics approaches.
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