ArticleNature. Mental health2025
Mapping Multimodal Risk Factors to Mental Health Outcomes.
Article in Nature. Mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The ABCD Study at 10: The NIH perspective on progress, impact, and the road ahead.Developmental cognitive neuroscience · 2026Article
- Challenges and opportunities of gap score methods for studying psychopathology resilience and vulnerability.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
A key challenge in predicting a person's state of mind is that there are a wide range of contributing factors that each have a subtle, yet significant, influence on mental health. We applied data mining techniques to identify the most important risk factors for predicting current symptoms and longitudinal outcomes from the Adolescent Brain Cognitive Developmental study (n = 11,552). Our results consistently revealed that social conflicts were the strongest predictors of psychopathology, especially family fighting and reputational damage between peers. Sex-differences also emerged as a critical factor for predicting long-term mental health outcomes. Neuroimaging derived metrics were consistently the least informative. While these findings provide novel insight into the developmental origins of psychopathology, our best performing models could only explain up to 40% of the variation between individuals. Future research is needed to obtain a more complete understanding of all the factors that meaningfully contribute to mental health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.