Evidence map›Paper›PMID 40969390›Full record

ArticleMaterials today. Bio2025

FAPI-engineered nanoprobe induces dual-cell ferroptosis therapy and enables light-up magnetic resonance imaging for gastric cancer peritoneal metastasis.

Cuiyin Zhao, Yingxin Ren, Jing Yang, Jiaqiang Jiang, Yudie Lu, Xiang Yu, Jie Feng, Zheyu Shen, Yanfeng Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cuiyin ZhaoDepartment of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Yingxin RenDepartment of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Jing YangSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Jiaqiang JiangDepartment of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Yudie LuSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Xiang YuDepartment of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.
Jie FengMedical Imaging Center, Nanfang Hospital, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Zheyu ShenSchool of Biomedical Engineering, Southern Medical University, 1023 Shatai South Road, Guangzhou, Guangdong, 510515, China.
Yanfeng HuDepartment of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, 510515, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer with peritoneal metastasis (GC PM) is associated with poor prognosis and limited therapeutic options. Cancer-associated fibroblasts (CAFs), as critical components of the tumor microenvironment (TME), drive tumor progression and confer treatment resistance. Single-cell RNA-seq analysis of gastric cancer specimens revealed that GPX4 expression was elevated in CAFs, indicating their intrinsic resistance to ferroptosis. To overcome this stromal barrier, we developed a multifunctional theranostic nanoprobe, integrating ferroptosis induction, CAF-targeted delivery, and magnetic resonance imaging (MRI). The nanoprobe co-delivers cisplatin (CDDP) and mesoporous superparamagnetic iron oxide nanoparticles (MSPIONs) to enhance lipid peroxidation and is further modified with fibroblast activation protein inhibitor (FAPI) to achieve selective accumulation in CAFs. A pH-responsive gadolinium-based contrast agent Gd-PASP (GP) allows

Indexed as

Cancer-associated fibroblastsDual-cell ferroptosisGastric cancer peritoneal metastasisMagnetic resonance imagingMesoporous superparamagnetic iron oxide nanoparticles

Identifiers

PMID40969390
PMCPMC12441704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.