Evidence map›Paper›PMID 40969344›Full record

ArticleFrontiers in veterinary science2025

Immunohistochemical characterization and potential prognostic relevance of dopamine signaling in canine pulmonary adenocarcinoma.

Alana R Kuzmik, Davis M Seelig, Luke H Hoeppner, Aaron Rendahl, Hannah Able, Amber Wolf-Ringwall, Jessica Lawrence

Abstract read
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alana R KuzmikDepartment of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States.
Davis M SeeligDepartment of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States.
Luke H HoeppnerMasonic Cancer Center, University of Minnesota, Minneapolis, MN, United States.
Aaron RendahlDepartment of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States.
Hannah AbleDepartment of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States.
Amber Wolf-RingwallDepartment of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States.
Jessica LawrenceDepartment of Veterinary Clinical Sciences, University of Minnesota, St. Paul, MN, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Dopamine signaling contributes to tumor progression in human lung adenocarcinoma. Isoforms of dopamine-and-cAMP-regulated phosphoprotein Mr. 32,000 (DARPP-32) are overexpressed in human lung adenocarcinoma and are associated with prognosis and development of treatment resistance. Despite similarities to human lung adenocarcinoma, dopamine signaling has not yet been evaluated in canine pulmonary adenocarcinoma. The objective of this study was to characterize immunohistochemical expression of DARPP-32 isoforms in canine pulmonary adenocarcinoma and assess associations with clinical variables, markers of proliferation and angiogenesis, and outcome. Methods: Immunohistochemistry for DARPP-32 isoforms DARPP Results: DARPP Conclusion: Collectively, data support further investigation of DARPP-32 protein signaling in canine lung adenocarcinoma.

Indexed as

cancerdopamine signalingEGFRpulmonary adenocarcinomaVEGFR2

Identifiers

PMID40969344
PMCPMC12442036

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.