Evidence map›Paper›PMID 40969242›Full record

ArticleLaryngoscope investigative otolaryngology2025

Other Than Complete Response in Oropharyngeal Carcinoma: Patient and Tumor-Related Factors.

Francesco Mattioli, Matteo Miglio, Edoardo Serafini, Roberto Tonelli, Edoardo Meneguzzi, Elisa D'Angelo, Roberta Depenni, Martina Napolitano, Massimo Dominici, Daniele Marchioni and 1 more

Abstract read
In one paragraph

Article in Laryngoscope investigative otolaryngology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Francesco MattioliDepartment of Otorhinolaryngology-Head and Neck Surgery University Hospital of Modena Modena Italy.
Matteo MiglioDepartment of Otorhinolaryngology-Head and Neck Surgery University Hospital of Modena Modena Italy.ORCID https://orcid.org/0000-0003-3398-036X
Edoardo SerafiniOtolaryngology and Audiology Unit IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico S. Orsola-Malpighi Bologna Italy.ORCID https://orcid.org/0000-0002-4519-1299
Roberto TonelliClinical and Experimental Medicine, Ph.D. Program University of Modena and Reggio Emilia Modena Italy.ORCID https://orcid.org/0000-0002-6202-0758
Edoardo MeneguzziUniversity of Modena and Reggio Emilia Modena Italy.
Elisa D'AngeloRadiation Oncology Unit Ospedale Bellaria Bologna Italy.
Roberta DepenniDepartment of Oncology and Hematology University Hospital of Modena Modena Italy.
Martina NapolitanoDepartment of Oncology and Hematology University Hospital of Modena Modena Italy.
Massimo DominiciUniversity of Modena and Reggio Emilia Modena Italy.
Daniele MarchioniDepartment of Otorhinolaryngology-Head and Neck Surgery University Hospital of Modena Modena Italy.
Federica BertoliniDepartment of Oncology and Hematology University Hospital of Modena Modena Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Oropharyngeal carcinoma represents a tumor with an increased concern in human health and treatment strategy. This study aims to identify any tumor or patient-related characteristics capable of predicting response to non-surgical curative treatment in a cohort of oropharyngeal squamous cell carcinoma and define oncological outcomes of overall survival and progression-free survival. Methods: A monocentric retrospective cohort study was performed, including 223 patients with non-metastatic oropharyngeal squamous cell carcinoma treated with curative intent with a non-surgical strategy. Patients were treated at the University Hospital of Modena (Italy) after a multidisciplinary evaluation between January 2010 and December 2021. The treatment response was assessed by using the RECIST 1.1 Criteria on imaging performed 3 months after treatment. Results: Tonsil subsite and stage I were independently associated with a complete treatment response (OR = 0.53, Conclusions: This retrospective study shows a possible stratification of patients with oropharyngeal squamous cell carcinoma based on factors that influence treatment response rate. The identification of a phenotype of a non-responding tumor could better define therapeutic and follow-up programs. Level of Evidence: 4.

Indexed as

human papillomavirusoropharyngeal squamous cell carcinomaprogressionrecurrenceresponse to treatment

Identifiers

PMID40969242
PMCPMC12442249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.