Evidence map›Paper›PMID 40969212›Full record

ArticleFrontiers in neurology2025

Ictal phase-amplitude coupling as a biomarker for seizure onset zone in neocortical epilepsy.

Kazuki Nishioka, Yasushi Iimura, Takumi Mitsuhashi, Hiroharu Suzuki, Tetsuya Ueda, Kazuki Nomura, Yao Miao, Toshihisa Tanaka, Hiroshi Otsubo, Hidenori Sugano and 1 more

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Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Kazuki NishiokaDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.
Yasushi IimuraDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.
Takumi MitsuhashiDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.
Hiroharu SuzukiDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.
Tetsuya UedaDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.
Kazuki NomuraDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.
Yao MiaoShenzhen Technology University, Shenzhen, China.
Toshihisa TanakaDepartment of Electrical Engineering and Computer Science, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Hiroshi OtsuboDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.
Hidenori SuganoDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.
Akihide KondoDepartment of Neurosurgery, Juntendo University, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess ictal phase-amplitude coupling (PAC) dynamics during seizure generation and explore whether ictal PAC analysis can help identify the seizure onset zone (SOZ) in neocortical epilepsy. Methods: We analyzed ictal intracranial electroencephalography recordings from 22 seizures in six patients with drug-resistant neocortical epilepsy who achieved International League Against Epilepsy Class I outcomes following resection surgery. PAC strength was quantified using the modulation index (MI), computed by coupling the amplitude of high-frequency bands (ripples: 80-200 Hz; fast ripples: 200-300 Hz) with the phase of slow-wave bands (1-2 Hz, 2-3 Hz, 3-4 Hz and 4-8 Hz). MI values were compared across SOZ, peri-SOZ (adjacent electrodes), and non-SOZ regions. Localization accuracy was evaluated using the area under the curve (AUC) from receiver operating characteristic curve analysis. Results: Across all PAC between ripples and slow wave bands, MI values were significantly higher in the SOZ compared to the peri-SOZ and non-SOZ regions ( Conclusion: Elevated MI during seizure onset accurately localized the SOZ in neocortical epilepsy. Ictal PAC may be a useful biomarker for identifying SOZ in neocortical epilepsy.

Indexed as

high-frequency oscillationsictal EEG analysismodulation indexneocortical epilepsyphase-amplitude coupling

Identifiers

PMID40969212
PMCPMC12440772

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