SynthesisFrontiers in aging neuroscience2025
Effects of transcranial alternating current stimulation on neurophysiologic motor function in Parkinson's patients: a systematic review and meta-analysis.
Synthesis in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Trial
- 20 Hz tACS engages striatal THINs to enhance β-band synchrony and motor drive.Frontiers in neuroscience · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This systematic review and meta-analysis aimed to evaluate whether tACS improves neurophysiologic motor function in patients with Parkinson's patients. Methods: We searched PubMed, Embase, Web of Science, and Cochrane Library for eligible studies from inception to March 2025. Measured outcomes included two indicators of neurophysiologic function: motor evoked potentials and short-term intracortical inhibition. The Cochrane risk of bias tool was used to evaluate the quality of the included literature, and extracted data were qualitatively synthesized and meta-analyzed. Results: Out of the 145 studies identified from the electronic databases, 7 fulfilled the inclusion criteria. Our results indicate that tACS significantly improved motor function in patients with PD compared to patients without tACS treatment. Motor function was assessed using motor evoked potentials (standardized mean deviation [SMD] = 2.65; 95% confidence interval [CI] = 2.02 to 3.27, Conclusion: Our findings suggested that tACS was strongly associated with improvements in motor evoked potentials and short-interval intracortical inhibition and could significantly improve neuromotor function. The results of this study provide additional evidence for the effectiveness of tACS and encourage the use of tACS in PD rehabilitation in clinical practice. Systematic review registration: The study protocol is registered with the International Prospective Register of Systematic Reviews under the registration number CRD420251016245.
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Registered trials
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