Evidence map›Paper›PMID 40969087›Full record

ArticleSensors (Basel, Switzerland)2025

Linking Neurocardiovascular Responses in the Active Stand Test to Adverse Outcomes: Insights from the Irish Longitudinal Study on Ageing (TILDA).

Feng Xue, Roman Romero-Ortuno

Abstract read
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Feng XueDiscipline of Medical Gerontology, School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland.
Roman Romero-OrtunoDiscipline of Medical Gerontology, School of Medicine, Trinity College Dublin, D02 PN40 Dublin, Ireland.ORCID 0000-0002-3882-7447

Funding

Taighde Éireann - Research Ireland 18/FRL/6188
6 · The paper itself

Abstract

backgroundThis study aimed to investigate the neurocardiovascular responses during an Active Stand (AS) test, utilizing both pre-processed and raw signals, to predict adverse health outcomes including orthostatic intolerance (OI) during the AS, and future falls and mortality.

methodsA total of 2794 participants from The Irish Longitudinal Study on Ageing (TILDA) were included. Continuous cardiovascular (heart rate (HR), systolic (sBP), and diastolic (dBP) blood pressure) and near infra-red spectroscopy-based neurovascular (tissue saturation index (TSI), oxygenated hemoglobin (O

resultsThe results demonstrated that raw (unprocessed) signals, particularly O

conclusionsThese findings highlight the potential utility of raw signal analysis in improving risk stratification for OI and mortality, with further studies needed to validate these findings and refine predictive models for clinical applications. This study underscores the importance of retaining raw data for certain physiological assessments and provides a foundation for future work in developing machine-learning models for early health outcome detection.

Indexed as

AgingAccidental FallsAgedAged, 80 and overBlood PressureFemaleHeart RateHumansIrelandLongitudinal StudiesMaleMiddle Agedactive standadverse health outcomesblood pressurebrain oxygenationcardiovascularcontinuous physiological monitoringneurocardiovascular responseneurovascularsignal preprocessingstatistical parametric mappingtissue saturation index (TSI)

Identifiers

PMID40969087
PMCPMC12158385

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.