ArticleSensors (Basel, Switzerland)2025
Portable Impedance Analyzer for FET-Based Biosensors with Embedded Analysis of Randles Circuits' Spectra.
Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Flexible Multimodal Neural Probe with Integrated Three-Electrode Aptameric Sensing for In Vivo Monitoring of Dopamine Dynamics and Neural Activity.ACS chemical neuroscience · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The electrochemical impedance spectroscopy (EIS) is a measurement method for characterizing bio-recognition events of a sensor, such as field-effect transistor-based biosensors (BioFETs). Due to the lack of portable impedance spectroscopes, EIS applies mainly in laboratories preventing application-oriented use in the field. This work presents a portable impedance analyzer (PIA) providing a 4-channel EIS of BioFETs. It performs the analysis of the recorded spectra by determining the charge transfer resistance Rct with a power-saving algorithm. Therefore, a circle is fitted into the Nyquist representation of the Randles circuit, from whose zero crossings Rct can be determined. The introduced algorithm was evaluated on 100 simulated spectra of Randles circuits. To analyze the overall system, an adjustable reference circuit was developed that simulates configurable Randles circuits. Additional measurements with pH-sensitive ion-sensitive field-effect transistors (ISFETs) demonstrate the application of the measurement system with electrochemical sensors. Using simulated spectra, the circular fitting is able to detect Rct with a median accuracy of 1.2% at an average nominal power of 40 mW and 3054 µs computing time. The PIA with the embedded implementation of the circuit fitting achieves a median error for R
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