Evidence map›Paper›PMID 40968879›Full record

ArticleSensors (Basel, Switzerland)2025

A Dual Immunosensor Based on Optical Weak Value Amplification for Simultaneous Detection of CA125 and HE4.

Bei Wang, Gengyu Liang, Lingqin Meng, Han Li, Zishuo Song, Yang Xu, Yonghong He, Deling Duan, Qiuxia Shi, Tian Guan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bei WangShenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0009-0000-9657-3919
Gengyu LiangShenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Lingqin MengDepartment of Psychological and Cognitive Sciences, Tsinghua University, Beijing 100190, China.
Han LiShenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.
Zishuo SongShenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0000-0002-7775-1983
Yang XuDepartment of Laboratory Medicine, Shenzhen Children's Hospital, Shenzhen 518038, China.
Yonghong HeShenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0000-0002-9964-8901
Deling DuanDepartment of Disease Control and Prevention, General Hospital of Southern Theater Command, Guangzhou 510010, China.
Qiuxia ShiDepartment of Laboratory Medicine, General Hospital of Southern Theater Command, Guangzhou 510010, China.
Tian GuanShenzhen Key Laboratory for Minimal Invasive Medical Technologies, Institute of Optical Imaging and Sensing, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China.ORCID 0000-0003-2509-2952
Ya GongDepartment of Laboratory Medicine, General Hospital of Southern Theater Command, Guangzhou 510010, China.

Funding

National Natural Science Foundation of China 82430062, 62405199Shenzhen Engineering Research Centre XMHT20230115004
6 · The paper itself

Abstract

Simultaneous detection of multiple biomarkers is essential for effective cancer screening. Taking ovarian cancer as an example, the combined detection of CA125 and HE4 has proven to be the most efficient and accurate among multiple biomarker combinations. In this study, we proposed a dual immunosensor based on weak value amplification (WVA) to detect ovarian cancer. By modifying the sensor surface through a self-assembled monolayer technique and utilizing recombinant protein G for antibody enrichment and directional capture, the sensor enables high-precision, simultaneous detection of CA125 and HE4, with detection limits of 5.39 U/mL and 1.79 ng/mL, respectively. Furthermore, the sensor demonstrates excellent specificity, effectively distinguishing target analytes from non-target molecules. This study provides a novel approach for early cancer screening and clinical diagnosis, highlighting the potential of WVA-based immunosensors in ovarian cancer detection.

Indexed as

Biosensing TechniquesCA-125 AntigenMembrane ProteinsOvarian NeoplasmsProteinsWAP Four-Disulfide Core Domain Protein 2Biomarkers, TumorFemaleHumansImmunoassayLimit of DetectionBiomarkers, TumorCA-125 AntigenMembrane ProteinsMUC16 protein, humanProteinsWAP Four-Disulfide Core Domain Protein 2WFDC2 protein, humanantibody immobilizationbiomarkersdual immunosensorovarian cancer detectionweak value amplification

Identifiers

PMID40968879
PMCPMC12157903

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.