ArticleSensors (Basel, Switzerland)2025
Rigid DNA Frameworks Anchored Transistor Enabled Ultrasensitive Detection of Aβ-42 in Serum.
Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Overview in Electrochemical and Electrical Biosensors for Determining Blood Protein Biomarkers of Alzheimer's Disease.Biosensors · 2026Review
- Nucleic Acid-Based Field-Effect Transistor Biosensors.Biosensors · 2026Review
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Authors and funding
4 authors.
Funding
Abstract
It is significant to search for ultrasensitive and accurate testing technology for point-of-care monitoring of common diseases at home; for example, monitoring the Aβ-42 level at any time is crucial for patients suffering from Alzheimer's disease. However, accurately monitoring the Aβ-42 level in serum is often thwarted by the challenges in sensitivity and specificity due to the multiplicated contaminations and intricated biofluid environments. Here, we develop a graphene field-effect transistor (G-FET) sensor modified with a type of rigid DNA framework aptamer-tetrahedral DNA nanostructure (TDN) for Aβ-42 detection in serum. The Aβ-42 specific aptamer combined with the rigid tetrahedral nanostructure achieves higher binding affinity and better specificity and anti-fouling ability. The detectable concentration reaches 5 × 10
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Registered trials
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