Evidence map›Paper›PMID 40968856›Full record

ArticleSensors (Basel, Switzerland)2025

Development of an E-Nose System for the Early Diagnosis of Sepsis During Mechanical Ventilation: A Porcine Feasibility Study.

Stefano Robbiani, Louwrina H Te Nijenhuis, Patricia A C Specht, Emanuele Zanni, Carmen Bax, Egbert G Mik, Floor A Harms, Willem van Weteringen, Laura Capelli, Raffaele L Dellacà

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stefano RobbianiDepartment of Electronics, Information, and Bioengineering, Politecnico di Milano, 20133 Milano, Italy.ORCID 0000-0002-0728-1613
Louwrina H Te NijenhuisDepartment of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0001-5094-2512
Patricia A C SpechtLaboratory of Experimental Anesthesiology, Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-6421-3035
Emanuele ZanniDepartment of Electronics, Information, and Bioengineering, Politecnico di Milano, 20133 Milano, Italy.
Carmen BaxDepartment of Chemistry, Materials, and Chemical Engineering Giulio Natta, Politecnico di Milano, 20133 Milano, Italy.ORCID 0000-0003-3820-2321
Egbert G MikLaboratory of Experimental Anesthesiology, Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.
Floor A HarmsLaboratory of Experimental Anesthesiology, Department of Anesthesiology, Erasmus MC, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0002-5478-4993
Willem van WeteringenDepartment of Neonatal and Pediatric Intensive Care, Division of Neonatology, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID 0000-0003-2667-3169
Laura CapelliDepartment of Chemistry, Materials, and Chemical Engineering Giulio Natta, Politecnico di Milano, 20133 Milano, Italy.ORCID 0000-0003-0002-3619
Raffaele L DellacàDepartment of Electronics, Information, and Bioengineering, Politecnico di Milano, 20133 Milano, Italy.ORCID 0000-0002-3672-4591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a severe systemic condition due to an extreme response of the body to an infection. It is responsible for a significant number of deaths worldwide, and is still difficult to diagnose early. In this study, a system was developed for exhaled breath sampling in mechanically ventilated patients at the intensive care unit (ICU), together with a custom-made electronic nose (e-Nose) device for detecting sepsis in exhaled breath. The diagnostic performance of this system was evaluated in an animal sepsis model. Ten pigs (LPS group) were administered lipopolysaccharide (LPS) to induce a systemic inflammatory response. Nine other pigs received a placebo solution (control group). Exhaled breath samples were collected in Nalophan

Indexed as

Electronic NoseRespiration, ArtificialSepsisAnimalsBreath TestsEarly DiagnosisFeasibility StudiesHumansLipopolysaccharidesSwineLipopolysaccharidesanimal modelelectronic noseexhaled breathlipopolysaccharidesepsis

Identifiers

PMID40968856
PMCPMC12157713

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.