Colorimetric Detection of Platinum (IV) Using 4-MethylSulfonylaniline-Modified Gold Nanoparticles in Lanthanum Carbonate API.

Zhongqiu Li, Longwei Li, Xiaotian Yang, Mengtao Duan, Zhiwei Li, Shiguo Sun

Abstract read

In one paragraph

Article in Sensors (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

6 authors.

Zhongqiu LiCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang 050018, China.

Longwei LiCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang 050018, China.

Xiaotian YangCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang 050018, China.

Mengtao DuanCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang 050018, China.

Zhiwei LiCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang 050018, China.

Shiguo SunCollege of Chemical and Pharmaceutical Engineering, Hebei University of Science and Technology, 26 Yuxiang Road, Shijiazhuang 050018, China.ORCID 0000-0003-3135-8542

Funding

Hebei Research Center of Pharmaceutical and Chemical Engineering 225676121Hthe Key R&D Program of Hebei Province 21377786Dthe Military Logistics open scientific research project CLB21C009the S & T Program of Hebei 22567607H

6 · The paper itself

Abstract

The control of elemental impurities is a critical step in the preparation of lanthanum carbonate, with platinum being one such impurity. Residual platinum is typically non-therapeutic and must be strictly controlled to ensure both safety and product quality. This paper describes a colorimetric method for determining platinum (IV) in solutions based on the anti-aggregation of gold nanoparticles modified with 4-methylsulfonylaniline (4-MESA). The presence of Britton-Robinson buffer induces the aggregation of the 4-MESA-AuNPs nanoparticle probe. However, when platinum (IV) is introduced, it disrupts the aggregation of the 4-MESA-AuNPs, causing a color change in the solution. The absorbance at 524 nm showed a strong linear correlation in the concentration range of 1.00 × 10

Indexed as

4-methylsulfonylaniline (4-MESA)active pharmaceutical ingredient (API)colorimetric detectiongold nanoparticlesPlatinum (IV)

Identifiers

PMID40968819

DOI10.3390/s25113274

PMCPMC12157221

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