ArticleInternational journal of surgery (London, England)2026
Social isolation, loneliness, genetic susceptibility, and the hazard of incident osteoporosis.
Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Adding salt to foods, genetic susceptibility, and risk of incident osteoporosis.The journal of nutrition, health & aging · 2026Article
- Social Isolation, Genetic Susceptibility, Systemic Inflammation and Risk of Abdominal Aortic Aneurysm: A UK Biobank Cohort Study.Healthcare (Basel, Switzerland) · 2026Article
- Joint trajectories of loneliness and depressive symptoms and risk of incident osteoporosis among middle-aged and older adults: a prospective cohort study.Frontiers in endocrinology · 2026Article
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Authors and funding
5 authors.
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Abstract
backgroundTo explore the association of social isolation and loneliness with risk of incident osteoporosis; and test the modification effects of genetic susceptibility.
methodsA total of 452 433 participants without osteoporosis at baseline were included from the UK Biobank cohort. Social isolation and loneliness were assessed at baseline via self-reported questionnaires. Cox regression models were used to observe the associations of social isolation and loneliness with risk of incident osteoporosis, as well as their joint associations with genetic susceptibility.
resultsDuring a median follow-up of 13.8 years, a total of 13 817 incident osteoporosis cases were recorded. Compared with participants with a social isolation index of 0, those with an index ≥2 had a higher risk of osteoporosis, with a hazard ratio (HR) of 1.18 (95% CI, 1.11-1.25) and a P -trend < 0.001. Compared to participants with an index of 0 for loneliness, the HR and 95% CI were 1.25 (95% CI, 1.17, 1.34) for those with a loneliness index of 2 ( P -trend < 0.001). In addition, we found that the increased risks of osteoporosis related to social isolation and loneliness were strengthened by the genetic susceptibility to osteoporosis.
conclusionsOur findings suggest that social isolation and loneliness are related to a higher risk of incident osteoporosis, and the associations were strengthened by the genetic susceptibility to osteoporosis.
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