ArticleClinical and experimental dental research2025
Penicillin Disrupts Dental Mineralization in Rats: A Comparative Study With Tetracycline Highlighting Prenatal and Postnatal Risks.
Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesPenicillin's impact on enamel defects remains understudied, particularly regarding its ability to cause structural issues even at therapeutic doses. MATERIAL AND
methodsPregnant Wistar rats received daily gavage from gestational day 13-22 with saline (control), 130 mg/kg tetracycline, 50 mg/kg penicillin, or 100 mg/kg penicillin. After birth, pups received the same treatment for 12 days. Upper first molars were analyzed for enamel/dentin thickness, maturation, and histopathological changes.
resultsTetracycline significantly reduced enamel and dentin thickness, disrupted their development, and caused flattening of the dentin-enamel junction (DEJ) compared to the control group. Penicillin at 100 mg/kg also significantly decreased enamel and dentin thickness, impaired their maturation, and led to DEJ flattening. At 50 mg/kg, penicillin did not significantly affect enamel and dentin thickness but still disrupted their development and caused DEJ flattening.
conclusionsPenicillin at 100 mg/kg adversely affected enamel and dentin development, causing significant defects similar to those caused by tetracycline, although the severity and mechanisms may differ. Even at 50 mg/kg, penicillin disrupted enamel and dentin development, underscoring the clinical relevance of these findings and the need for caution when prescribing penicillin during pregnancy, even at lower doses, due to its potential to disrupt dental development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.