ArticleAllergy2026
Colostrum as a Protective Factor Against Peanut Allergy: Evidence From a Birth Cohort.
Article in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Immune development in early life.Nature immunology · 2026Review
- Immunonutrition: Feeding the gut, skin, and immune system.Asia Pacific allergy · 2026Review
- The involvement of human breastmilk-derived extracellular vesicles in the development of infant atopic sensitization.Allergologie select · 2026Review
- Impact of Using Cow's Milk Formula During the First Three Postnatal Days and Other Etiological Factors on the Development of Cow's Milk Protein Allergy.Journal of clinical medicine · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundFood allergy affects families' quality of life, can be lifelong and life-threatening, urging the identification of early modifiable risk factors. Formula feeding in the first days of life may increase the risk of cow's milk allergy, a risk often attributed to cow's milk allergens exposure. Early formula feeding also reduces the colostrum intake, the first 3 days' milk, which is rich in bioactive compounds critical for immune and gut health. This study investigates whether partial colostrum feeding increases the risk of food allergy beyond cow's milk.
methodsData from 666 mother-infant pairs in the Australian ORIGINS cohort categorised neonates as exclusive colostrum-fed (ECF, only breastmilk) or partial colostrum-fed (PCF, formula plus breastmilk) within the first 3 days. IgE-mediated food allergy (egg, peanut, cow's milk, cashew) at 12-18 months was determined by skin prick tests and maternal-reported immediate reactions to allergens.
resultsPCF prevalence was 46%. PCF infants showed an increased risk of peanut allergy [aOR (95% CI) 4.47 (1.04-19.12)] and multiple food allergies [aOR 11.44 (1.48-88.55)] compared to ECF infants. Risk was greater in PCF infants with later (> 7 M) peanut introduction [aOR 5.45 (1.18-25.11)], while ECF infants maintained a low risk regardless of timing. To disentangle the effect of reduced colostrum intake from formula feeding in PCF infants, we analysed the association between the number of colostrum feeds and allergic outcomes. No peanut allergy cases occurred in infants receiving nine or more colostrum feeds per day within their first 72 h, regardless of formula feeding.
conclusionPartial colostrum feeding may be an overlooked risk factor for peanut and multiple food allergies. With over a third of neonates globally partially colostrum-fed, findings highlight the importance of promoting colostrum feeding and exploring colostrum-based therapies for high-risk infants.
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