Evidence map›Paper›PMID 40968360›Full record

Observational studyBMC pregnancy and childbirth2025

The role of the Mod-MPI in identifying cardiac dysfunction in FGR fetuses stratified by umbilical artery flow abnormalities.

Tuğçe Arslanoğlu, Kübra Kurt Bilirer, Sezin Uludağ, Hale Çetin Arslan, Merih Çetinkaya, Banu Kılıçoğlu Dane, İbrahim Polat

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07551232 (Evaluation of Myocardial Performance Index in Cases of Fetal Anemia), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07551232 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Evaluation of Myocardial Performance Index in Cases of Fetal Anemia: A Prospective Study

TypeobservationalSponsorAssiut UniversityRan2026 to 2028Enrolled15ConditionsFetal Anemia, Fetal Echocardiography
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tuğçe ArslanoğluObstetrics and Gynecology Clinic, Department of Perinatology, University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey. drtugcetunc@gmail.com.
Kübra Kurt BilirerObstetrics and Gynecology Clinic, Department of Perinatology, University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey.
Sezin UludağObstetrics and Gynecology Clinic, Department of Perinatology, University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
Hale Çetin ArslanObstetrics and Gynecology Clinic, University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, Istanbul, Turkey.
Merih ÇetinkayaDepartment of Pediatrics, Division of Neonatology, University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey.
Banu Kılıçoğlu DaneObstetrics and Gynecology Clinic, Department of Perinatology, University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey.
İbrahim PolatObstetrics and Gynecology Clinic, Department of Perinatology, University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFetal growth restriction (FGR) is a major cause of perinatal morbidity and mortality. In patients with absent end-diastolic flow (AEDF) in the umbilical artery, placental insufficiency is typically severe, and adverse neonatal outcomes are common. The modified myocardial performance index (Mod-MPI) provides a noninvasive assessment of global fetal cardiac function; however, its relationship with Doppler findings and perinatal outcomes in patients with FGR remains under investigation.

methodsThis prospective observational study included 217 singleton pregnancies between 24 + 0 and 36 + 0 weeks of gestation. Among these, 103 fetuses were diagnosed with FGR and subdivided on the basis of the presence (n = 47) or absence (n = 56) of AEDF. The control group included 114 gestational age-matched fetuses with normal growth and Doppler findings. Left ventricular Mod-MPI and cardiac time intervals were measured via a standardized pulsed-wave Doppler technique on the basis of valvular motion timing. The mitral inflow E- and A-wave velocities were also recorded. Perinatal outcomes such as gestational age at delivery, birth weight, 5-minute Apgar score, and NICU admission were compared.

resultsAlthough the mean Mod-MPI values were not significantly different between the groups (p = 0.38), AEDF-positive fetuses had shorter ejection times and significantly lower mitral E and A velocities (p < 0.001). These findings indicate impaired diastolic function. Compared with other groups, AEDF-positive fetuses were delivered earlier, had lower birth weights, and had higher NICU admission rates (p < 0.01).

conclusionsIn fetuses with FGR, the presence of AEDF is associated with early signs of cardiac dysfunction and poor perinatal outcomes. While the mean Mod-MPI may not differ markedly, its components reflect significant hemodynamic compromise. Mod-MPI may be a useful adjunct for monitoring fetal well-being in cases of severe placental insufficiency.

Indexed as

Fetal Growth RetardationFetal HeartUmbilical ArteriesAdultBlood Flow VelocityFemaleGestational AgeHumansInfant, NewbornPlacental InsufficiencyPregnancyPregnancy OutcomeProspective StudiesUltrasonography, PrenatalAEDFCardiac dysfunctionFetal echocardiographyFGRMPI

Identifiers

PMID40968360
PMCPMC12447613

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.