SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
Stroke risk in cancer survivors: A meta-analysis and meta regression.
Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIt is suggested that survivors of different types of cancer may have an increased risk of stroke. Our study aims to evaluate cancer patients and non-cancer controls by analyzing stroke events in each group. Previous studies concluded that certain types of cancer increased stroke risk, however, their results had significant heterogeneity and statistical concerns.
methodsMedline, Embase, and Cochrane databases were systematically searched until February 18th, 2024, assessing stroke in cancer survivor patients compared to the global population. Data were examined using the Mantel-Haenszel method and 95% CIs. Heterogeneity was assessed using I² statistics. Rstudio software, version 4.2.3., was used for statistical analysis.
resultsA total of 18 studies were included, and stroke was reported in both cancer and non-cancer groups. Breast cancer (HR 1.09; 95% CI 1.02-1.17; p = 0.01; I²= 0%), Central Nervous System cancers (HR 2.47; 95% CI 1.01-6.01; p = 0.047; I²= 78%), cervical cancers (HR 1.58; 95% CI 1.19-2.09; p = 0.001; I²= 0%), head and neck cancers (HR 1.4439; 95% CI 1.3095-1.5922; p < 0.001; I²=31.5%), lung cancers (HR 1.60; 95% CI 1.40-1.83; p < 0.001; I²=67%), multiple myeloma (HR 1.58; 95% CI 1.32-1.89; p < 0.001; I²= 49%), nasopharyngeal cancers (HR 1.9178; 95% CI 1.3358-2.7533; p < 0.001; I²=89.7%), oesophageal cancers (HR 1.33; 95% CI 1.07-1.65; p = 0.009; I²= 0%), ovarian cancers (HR 1.33; 95% CI 1.07-1.65; p = 0.01; I²= 38%), pancreatic cancers (HR 2,70; 95% CI 2.34-3.11; p < 0.001; I²= 0%) and rectum cancers (HR 1.29; 95% CI 1.01-1.63; p = 0.04; I²= 0%) showed statistically significant differences between groups in favor of non-cancer controls.
conclusionsIn this meta-analysis, the stroke risk was increased in all cancers that reached statistical significance. Furthermore, our study brings relevant data to the body of literature concerning this long-term clinical uncertainty.
Indexed as
Identifiers
40968352What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.