Strawberry-shaped hybrid dendritic prodrug-based unimolecular micelles for improved drug release performance and real-time in-site fluorescence imaging.

Wei Chen, Peng Liu

Abstract read

In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

2 authors.

Wei ChenState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.

Peng LiuState Key Laboratory of Natural Product Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China. pliu@lzu.edu.cn.

Funding

Natural Science Foundation of Gansu Province, China Grant No. 18JR3RA271

6 · The paper itself

Abstract

Dendritic polymer-based unimolecular micelles have attracted more interest in tumor chemotherapy. However, the drug release behavior was significantly affected by the hydrophilic-hydrophobic property of the dendritic cores. In the present work, carbon quantum dot (CQD) was used as a bridge between the dendritic core and drug to achieve a better drug release performance for imaging-mediated therapy. Strawberry-shaped hybrid prodrug was designed with a DOX content of 16.7%. The resultant hybrid unimolecular micelles with a mean hydrodynamic diameter of around 82 nm showed sustained acid-triggered DOX release with minimized drug leakage, possessing enhanced anti-tumor efficacy compared to free DOX. Furthermore, the fluorescence of the hybrid unimolecular micelles could be turned on for imaging-guided cancer therapy after tumor intracellular drug release.

Indexed as

DendrimersDoxorubicinDrug CarriersMicellesOptical ImagingProdrugsAntineoplastic AgentsCarbonCell SurvivalDrug LiberationHumansQuantum DotsAntineoplastic AgentsCarbonDendrimersDoxorubicinDrug CarriersMicellesProdrugsCarbon quantum dotDendritic polymer prodrugHybrid unimolecular micellesImproved drug releaseTumor theranostics

Identifiers

PMID40968329

DOI10.1007/s00604-025-07546-7

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.