ArticleNature genetics2025
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks.
Abstract read
In one paragraph
Article in Nature genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Article
- Article
- Functional and computational interrogation of juvenile idiopathic arthritis risk loci in CD4+ T cells.HGG advances · 2026Article
- Autoimmune non-coding variants perturb transcription factor-cofactor complex assembly linked to enhancer activity.bioRxiv : the preprint server for biology · 2026Article
- Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026Article
- Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cells.bioRxiv : the preprint server for biology · 2026Article
- Functional and Computational Interrogation of the Juvenile Idiopathic Arthritis Risk Loci Identifies Candidate Causal SNPs and Target Genes in CD4+ T cells.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
- Update of
Authors and funding
17 authors.
Ching-Huang HoBenaroya Research Institute, Center for Systems Immunology, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8359-8068
Maxwell A DippelBenaroya Research Institute, Center for Systems Immunology, Seattle, WA, USA.
Meghan S McQuadeBenaroya Research Institute, Center for Systems Immunology, Seattle, WA, USA.
LeAnn P NguyenBenaroya Research Institute, Center for Systems Immunology, Seattle, WA, USA.
Arpit MishraBenaroya Research Institute, Center for Translational Immunology, Seattle, WA, USA.
Stephan PribitzerBenaroya Research Institute, Center for Systems Immunology, Seattle, WA, USA.
Samantha HardyBenaroya Research Institute, Center for Systems Immunology, Seattle, WA, USA.
Harshpreet ChandokThe Jackson Laboratory, Bar Harbor, ME, USA.
Florence M ChardonUniversity of Washington, Department of Genome Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-8858-989X
Troy A McDiarmidUniversity of Washington, Department of Genome Sciences, Seattle, WA, USA.
Hannah A DeBergBenaroya Research Institute, Center for Systems Immunology, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5263-158X
Jane H BucknerBenaroya Research Institute, Center for Translational Immunology, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9005-1885
Jay ShendureUniversity of Washington, Department of Genome Sciences, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-1516-1865
Carl G de BoerUniversity of British Columbia, School of Biomedical Engineering, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-8935-5921
Michael H GuoUniversity of Pennsylvania, Department of Neurology, Philadelphia, PA, USA.
Ryan TewheyThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID http://orcid.org/0000-0002-4607-8001
John P RayBenaroya Research Institute, Center for Systems Immunology, Seattle, WA, USA. jray@benaroyaresearch.org.ORCID http://orcid.org/0000-0001-7294-4260
Funding
T cells promoting transitions toward autoimmunityU01AI176320 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Jane Hoyt Buckner, S Alice Long · 2023 to 2026
$4.7MBiophysical and functional characterization of immune-related regulatory elements and noncoding variantsR01AI151051 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI SIGGERS, TREVOR · 2020 to 2024
$2.8MInvestigating Genetic and Epigenetic Control of T Cell Function in AutoimmunityDP2AI183504 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI John Philip Ray · 2023 to 2026
$2.6MFunctional Mapping of Enhancer Conservation Between Species to Enable Mechanistic Insights into Polygenic DiseaseR35HG011329 · NHGRI · JACKSON LABORATORY · PI TEWHEY, RYAN · 2021 to 2025
$2.6MGenetic variants guiding pathogenicity of colitogenic T cellsR01DK140972 · NIDDK · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI Oliver James Harrison, John Philip Ray · 2024 to 2026
$1.5MShort tandem repeats as a novel genetic driver of Alzheimer's diseaseK08AG086591 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Michael Haoming Guo · 2024 to 2026
$429kPrioritizing and Characterizing T Cell-Relevant Genetic Variants Associated with Autoimmune DiseasesK22AI153648 · NIAID · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI RAY, JOHN PHILIP · 2021 to 2022
$270kCanadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology) Banting Postdoctoral FellowshipCrohn's and Colitis Foundation (Crohn's & Colitis Foundation) 1158945Michael Smith Foundation for Health Research (MSFHR) British Columbia ScholarNHGRI NIH HHS R35 HG011329NIAID NIH HHS DP2 AI183504NIAID NIH HHS K22 AI153648NIAID NIH HHS R01 AI151051NIAID NIH HHS U01 AI176320NIA NIH HHS K08 AG086591NIDDK NIH HHS R01 DK140972
Abstract
Genetic variants associated with autoimmune diseases are highly enriched within putative cis-regulatory regions of CD4
Indexed as
Autoimmune DiseasesCD4-Positive T-LymphocytesEpigenesis, GeneticT-LymphocytesAllelesGene Expression RegulationGene Regulatory NetworksGenetic Predisposition to DiseaseGenetic VariationHumansLymphocyte ActivationPolymorphism, Single NucleotideSingle-Cell Analysis
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.