Evidence map›Paper›PMID 40968266›Full record

ArticleJournal of computer-aided molecular design2025

Assembling of phenyl substituted halogens in the C3-position of substituted isatins by mono wave assisted synthesis: development of a new class of monoamine oxidase inhibitors.

Della Grace Thomas Parambi, Stephanus J Cloete, Sunil Kumar, Tariq Ghazi Alsahli, Arafa Musa, Sumera Qasim, Muzammil Kabier, Sachithra Thazhathuveedu Sudevan, Saranya Kattil Parmbil, Anél Petzer and 2 more

Abstract readLetter
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In one paragraph

Article in Journal of computer-aided molecular design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Della Grace Thomas Parambi *Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia. dellajesto@gmail.com.
Stephanus J Cloete *Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa.
Sunil Kumar *Department of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India.
Tariq Ghazi AlsahliDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia.
Arafa MusaDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia.
Sumera QasimDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, 72341, Sakaka, Aljouf, Saudi Arabia.
Muzammil KabierDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India.
Sachithra Thazhathuveedu SudevanDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India.
Saranya Kattil ParmbilDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India.
Anél PetzerCentre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa.
Jacobus P PetzerCentre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, 2520, South Africa. jacques.petzer@nwu.ac.za.
Bijo MathewDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, 682041, India. bijovilaventgu@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of ten chloro- and bromo-substituted isatin derivatives were synthesized and evaluated for their ability to inhibit the monoamine oxidase (MAO) enzymes. All compounds demonstrated more potent inhibition of MAO-A compared to MAO-B. The most potent MAO-A inhibitor was HIB2 (IC

Indexed as

HalogensIsatinMonoamine OxidaseMonoamine Oxidase InhibitorsBlood-Brain BarrierHumansHydrogen BondingMolecular Docking SimulationStructure-Activity RelationshipHalogensIsatinMonoamine OxidaseMonoamine Oxidase InhibitorsHydrazoneInhibitionIsatinKineticsMolecular dynamicsMonoamine oxidaseReversibility

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.