Evidence map›Paper›PMID 40968221›Full record

ArticleGeroScience2026

Acute bilateral central deafness following cardioembolic ischemic stroke: insights from EEG spectral and connectivity analysis.

Alessia Cacciotti, Francesca Miraglia, Giovanni Siconolfi, Francesco Iodice, Antonio Marrone, Cristiano Pecchioli, Petra Vukoja, Paolo Maria Rossini, Fabrizio Vecchio

Abstract readCase Reports
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alessia CacciottiBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Via Val Cannuta, 247, 00166, Rome, Italy.
Francesca MiragliaBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Via Val Cannuta, 247, 00166, Rome, Italy.
Giovanni SiconolfiDepartment of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.
Francesco IodiceBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Via Val Cannuta, 247, 00166, Rome, Italy.
Antonio MarroneBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Via Val Cannuta, 247, 00166, Rome, Italy.
Cristiano PecchioliBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Via Val Cannuta, 247, 00166, Rome, Italy.
Petra VukojaBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Via Val Cannuta, 247, 00166, Rome, Italy.
Paolo Maria RossiniDepartment of Neurosciences & Neurorehabilitation, IRCCS San Raffaele Roma, Rome, Italy.
Fabrizio VecchioBrain Connectivity Laboratory, Department of Neuroscience and Neurorehabilitation, IRCCS San Raffaele Roma, Via Val Cannuta, 247, 00166, Rome, Italy. fabrizio.vecchio@uniecampus.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke is a leading cause of adult disability, with outcomes depending on the lesion's location and severity. While motor and language deficits are common, rare manifestations like central auditory dysfunction can be equally debilitating. This case report presents a 57-year-old woman who developed acute bilateral central deafness following a cardioembolic ischemic stroke. To investigate underlying mechanisms, advanced EEG analyses were conducted, including spectral power analysis and eLORETA-based functional connectivity, across key frequency bands. The Small World index was applied to evaluate changes in brain network organization over 6 weeks. Results revealed disrupted connectivity in bilateral auditory and associative cortices, with significant spectral power alterations. Alpha and gamma bands showed distinct recovery dynamics, while connectivity metrics indicated a shift toward global integration, possibly compensating for local disconnections. These findings demonstrate the utility of EEG biomarkers in monitoring post-stroke neural reorganization and support their potential role in guiding rehabilitation for sensory deficits.

Indexed as

ElectroencephalographyEmbolic StrokeHearing Loss, CentralIschemic StrokeFemaleHumansMiddle AgedCentral auditory dysfunctionConnectivityEEGNeurorehabilitationPower spectral density (PSD)Stroke

Identifiers

PMID40968221
PMCPMC13356100

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.