ArticleLab animal2025
Impact of prolonged isoflurane or ketamine-xylazine anesthesia with or without buprenorphine and oxygen on mouse vitals and immune responses.
Article in Lab animal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Extracorporeal near-infrared-activated antimicrobial photodynamic therapy for pneumonia using an ICG-polymer formulation.Biophotonics discovery · 2026Article
- The impact of pericardial disruption on heart function and remodeling after myocardial infarction in mice.The international journal of cardiovascular imaging · 2026Article
- Protocol for establishing a mouse model of bilateral maxillary first molar extraction to study alveolar bone healing.STAR protocols · 2026Article
- Design and Validation of an Arduino-Based, Cost-Effective Heated Anesthesia Induction Chamber for Mice.Journal of the American Association for Laboratory Animal Science : JAALAS · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Anesthesia is indispensable for minimizing stress during invasive procedures. However, anesthesia can induce undesired effects on the organism and its physiological homeostasis. In experiments involving animals, these consequences may reduce animal welfare and alter experimental outcomes. Moreover, most of the studies characterizing the effects of murine anesthetic protocols on animal welfare do not explore the impact of prolonged anesthesia for procedures lasting more than 2 h. Here we investigated the effect of prolonged anesthesia on vital parameters and immune responses to vaccination, comparing isoflurane (Iso), ketamine-xylazine (KX), and KX with oxygen supplementation (KXO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.