ArticleBritish journal of cancer2025
Birthweight, height, and body mass index in relation to the expression of stem cell markers among women with benign breast biopsies in the Nurses' Health Study II.
Hannah Oh, Lusine Yaghjyan, Yujing J Heng, Gabrielle M Baker, Brian R Sardella, Matt B Mahoney, Divya Murthy, Bernard Rosner, Rulla M Tamimi
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In one paragraphArticle in British journal of cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Lusine Yaghjyan *Department of Epidemiology, College of Public Health and Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.
Gabrielle M BakerDepartment of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Brian R SardellaDepartment of Pathology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Matt B MahoneyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Divya MurthyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Rulla M Tamimi *Department of Population Health Sciences, Weill Cornell Medicine, New York, NY, USA.
Funding
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, TAMIMI, RULLA M · 2000 to 2019
$77.8MLife Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4MLong Term Multidisciplinary Study of Cancer in Women: The Nurses Health StudyUM1CA186107 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI ELIASSEN, A. HEATHER, STAMPFER, MEIR · 2014 to 2023
$22.3MWhole Genome Association Study of Mammographic DensityR01CA131332 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2009 to 2012
$1.9MMammographic density and texture features in relation to breast cancer riskR01CA175080 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TAMIMI, RULLA M · 2013 to 2016
$1.7MThe role of breast stem cells in breast cancer etiology and risk predictionR01CA240341 · NCI · UNIVERSITY OF FLORIDA · PI YAGHJYAN, LUSINE · 2020 to 2023
$1.4MKorea University (KU) K2302991National Research Foundation of Korea (NRF) NRF-2023S1A5C2A03095169NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA131332NCI NIH HHS R01 CA175080NCI NIH HHS R01 CA240341NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA186107U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA131332U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA175080U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA240341
6 · The paper itselfAbstract
backgroundThe amount and activity of breast stem cell population may play an important role in breast carcinogenesis. However, little is known about whether early-life and adult anthropometric measures, including body mass index (BMI), birthweight, and height, are associated with stem cell marker expressions in non-cancerous breast tissue.
methodsAmong 730 women with biopsy-confirmed benign breast disease (BBD) in the Nurses' Health Study II, we quantified immunohistochemical staining of stem cell markers (CD44, CD24, ALDH1A1) in histopathologically normal epithelial and stromal breast tissue. Linear regression was conducted to estimate the associations of anthropometric measures with stem cell marker expression, adjusting for potential confounders.
resultsBMI at age 18 (≥23.0 vs. <19.0 kg/m
conclusionAdiposity measures may be associated with stem cell marker expression among cancer-free women.
Indexed as
Birth WeightBody HeightBody Mass IndexBreastBreast DiseasesStem CellsAdultAldehyde Dehydrogenase 1 FamilyBiomarkersBiopsyBreast NeoplasmsCD24 AntigenFemaleHumansHyaluronan ReceptorsMiddle AgedAldehyde Dehydrogenase 1 FamilyALDH1A1 protein, humanBiomarkersCD24 AntigenCD24 protein, humanCD44 protein, humanHyaluronan ReceptorsRetinal Dehydrogenase
Identifiers
PMID40968174
PMCPMC12516083
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