ArticleNature plants2025
Stem cell regulators drive a G1 duration gradient during plant root development.
Article in Nature plants, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cyclin' Through the Root: Developmental Control of Cell Cycle Progression in theAnnual review of cell and developmental biology · 2026Review
- The (un)likelihood of clock-driven lateral root priming; a modeling exploration.The Plant cell · 2026Article
- Cell cycle in plant development and reprogramming.Development (Cambridge, England) · 2026Review
- Article
- Computational modeling of plant root development: the art and the science.The New phytologist · 2025Review
- Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration.Developmental cell · 2025Article
- A Method to Visualize Cell Proliferation ofPlant direct · 2025Article
- Glutathione accelerates the cell cycle and cellular reprogramming in plant regeneration.bioRxiv : the preprint server for biology · 2024Article
- A Journey to the Core of the Plant Cell Cycle.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Organogenesis relies on the coordination of cell proliferation with developmental programs. In meristems, where new plant organs initiate, the cell proliferation potential depends on stem cell regulators, but the mechanisms linking their local activity with the cell cycle machinery remain unknown. Here we show a positional gradient of G1 duration in the Arabidopsis root meristem spanning from ~2 h near the meristem boundary to more than 20 h in the early stem cell derivatives. Mutations in the stem cell regulatory PLETHORA (PLT) genes and the cell cycle RETINOBLASTOMA-RELATED 1 gene shortened G1 duration, abolishing the G1 duration gradient, whereas PLT2 overexpression increased G1 duration. Data-driven computer modelling supported the presence of an incoherent feed-forward loop. We found that PLT genes are drivers with simultaneous and opposing roles in maintaining stem cell activity and inhibiting G1 progression through a cascade involving the CDK inhibitor KRP5, a PLT target and RETINOBLASTOMA-RELATED 1. The G1 duration gradient is developmentally regulated and established after the emergence of lateral roots from the primary root and correlates with increased tolerance to genome damage. Our study establishes a previously undescribed proximal-distal G1 duration gradient during root development that is shaped by the balanced activity of stem cell maintenance and cell cycle regulators.
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Registered trials
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