Evidence map›Paper›PMID 40968134›Full record

ArticleSignal transduction and targeted therapy2025

Ultrasound activated herbal bio-heterojunctions for self-catalytic regulation and bacterial cuproptosis-like death in the treatment of implant infection.

Yan Yue, Shuoyuan Li, Qiang Su, Xufeng Wan, Qiaochu Li, Zhuang Zhang, Hong Xu, Fuyuan Zheng, Yangming Zhang, Le Tong and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Signal transduction and targeted therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yan Yue *Orthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Shuoyuan Li *Orthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qiang Su *Orthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xufeng WanOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qiaochu LiDepartment of Orthopedics, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
Zhuang ZhangOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Hong XuOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Fuyuan ZhengOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yangming ZhangOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Le TongDepartment of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.
Jian CaoOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Long ZhaoOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xiaoting ChenAnimal Experimental Center, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qi LiOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yi ZengOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Haoyang WangOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yi DengSchool of Chemical Engineering, Sichuan University, Chengdu, 610065, China. dengyibandeng@scu.edu.cn.
Zongke ZhouOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China. zongke@126.com.
Duan WangOrthopedic Research Institute and Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, 610041, China. wangduan_bone@163.com.ORCID 0000-0001-5487-4414

Funding

National Natural Science Foundation of China (National Science Foundation of China) No.32271392National Natural Science Foundation of China (National Science Foundation of China) No.82102542National Natural Science Foundation of China (National Science Foundation of China) No.82172394National Natural Science Foundation of China (National Science Foundation of China) No.82472402National Natural Science Foundation of China (National Science Foundation of China) No.U22A2080
6 · The paper itself

Abstract

Conventional antibiotic strategies often fail to consistently suppress escaping planktonic bacteria and even induce antibiotic resistance, allowing implant-associated infections (IAIs) to persist. In this study, we demonstrated an antibiotic-free coating engineered with an herbal bioheterojunction featuring a shell-in-shell structure where Cu

Indexed as

Anti-Bacterial AgentsCopperProsthesis-Related InfectionsAnimalsCurcuminEscherichia coliHumansMiceProstheses and ImplantsReactive Oxygen SpeciesStaphylococcus aureusStrontiumAnti-Bacterial AgentsCopperCurcuminReactive Oxygen SpeciesStrontium

Identifiers

PMID40968134
PMCPMC12446443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.