Bioinspired transfer methylation enabled by a photoactive reagent.

Ding Zhang, Weiqiu Liang, Zhihan Zhang, Lida Tan, Zehao Yuan, Zhennan Hu, Zhibo Liu, Chao-Jun Li, Jianbin Li

Abstract read

In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ding Zhang *School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.

Weiqiu Liang *Beijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China.

Zhihan Zhang *College of Chemistry, Central China Normal University, Wuhan, Hubei, China. zhihanzhang@ccnu.edu.cn.ORCID http://orcid.org/0000-0002-1758-3914

Lida TanDepartment of Chemistry, FRQNT Centre for Green Chemistry and Catalysis, McGill University, Montreal, Quebec, Canada.

Zehao YuanSchool of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.ORCID http://orcid.org/0009-0000-8560-189X

Zhennan HuSchool of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong, China.

Zhibo LiuBeijing National Laboratory for Molecular Sciences, Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing, China. zbliu@pku.edu.cn.ORCID http://orcid.org/0000-0002-5587-4165

Chao-Jun LiDepartment of Chemistry, FRQNT Centre for Green Chemistry and Catalysis, McGill University, Montreal, Quebec, Canada. cj.li@mcgill.ca.ORCID http://orcid.org/0000-0002-3859-8824

Jianbin LiSchool of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong, China. jianbinli@cuhk.edu.cn.ORCID http://orcid.org/0000-0003-4956-7625

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021YFA1601400National Natural Science Foundation of China (National Science Foundation of China) NSFC22203034National Natural Science Foundation of China (National Science Foundation of China) NSFC22401240

6 · The paper itself

Abstract

Radical methylation ranks among the most important yet challenging transformations in chemistry and biology, which often involves small and unstable radical intermediates, such as the methyl radical, and results in low reactivity and poor selectivity. Herein, we report a photoactive, biomimetic reagent to address some facets of these challenges by leveraging a bulky and stabilised α-aminomethyl radical, which can offer enhanced control over radical generation and transfer. Our bioinspired transfer methylation protocol enables direct and selective C(sp

Identifiers

PMID40968115

DOI10.1038/s41467-025-61857-0

PMCPMC12446463

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.