Evidence map›Paper›PMID 40968014›Full record

ArticleAJNR. American journal of neuroradiology2025

Differentiation between Nonenhancing Tumor in Glioblastoma and Vasogenic Edema Using Diffusion-Weighted and Dynamic Susceptibility Contrast MR Imaging.

Sahar Alizada, Yasmin Aly, Hongbo Bao, Dhairya Lakhani, Vivek Yedavalli, Haris Sair, Janet Mei

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PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sahar AlizadaFrom the Department of Neuroradiology (S.A.), The University of Texas MD Anderson Cancer Center, Houston, Texas.ORCID https://orcid.org/0000-0001-5284-414X
Yasmin AlyDepartment of Neuroradiology (Y.A., H.B., D.L., V.Y., H.S., J.M.), The Johns Hopkins Hospital, Baltimore, Maryland.ORCID https://orcid.org/0009-0007-8829-4582
Hongbo BaoDepartment of Neuroradiology (Y.A., H.B., D.L., V.Y., H.S., J.M.), The Johns Hopkins Hospital, Baltimore, Maryland.ORCID https://orcid.org/0000-0003-1043-6951
Dhairya LakhaniDepartment of Neuroradiology (Y.A., H.B., D.L., V.Y., H.S., J.M.), The Johns Hopkins Hospital, Baltimore, Maryland.ORCID https://orcid.org/0000-0001-7577-1887
Vivek YedavalliDepartment of Neuroradiology (Y.A., H.B., D.L., V.Y., H.S., J.M.), The Johns Hopkins Hospital, Baltimore, Maryland.
Haris SairDepartment of Neuroradiology (Y.A., H.B., D.L., V.Y., H.S., J.M.), The Johns Hopkins Hospital, Baltimore, Maryland.ORCID https://orcid.org/0000-0002-5077-0471
Janet MeiDepartment of Neuroradiology (Y.A., H.B., D.L., V.Y., H.S., J.M.), The Johns Hopkins Hospital, Baltimore, Maryland jmei12@jh.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDifferentiating nonenhancing glioblastoma from vasogenic edema remains a challenge in neuroimaging. This study evaluates the utility of diffusion-weighted and dynamic susceptibility contrast MR imaging, particularly ADC and relative CBV (rCBV), in distinguishing these entities. MATERIALS AND

methodsWe retrospectively analyzed 111 patients diagnosed with glioblastoma with available pretreatment MRIs from January 1, 2022, to December 31, 2023, including 13 patients with 15 solid, nonenhancing glioblastoma lesions and 98 patients with perilesional nonenhancing T2-FLAIR hyperintensity surrounding enhancing glioblastomas. Their ADC and rCBV values were compared with those of 30 brain metastatic lesions age- and sex-matched to solid, nonenhancing glioblastoma lesions. Receiver operating characteristic analysis was performed to determine optimal ADC and rCBV thresholds for classification.

resultsSolid, nonenhancing glioblastomas had significantly lower mean ADC values and higher mean rCBV values compared with vasogenic edema (1.08 [SD, 0.22] × 10

conclusionsDiffusion- and perfusion-weighted MR imaging, particularly ADC and rCBV measurements, provide valuable biomarkers for differentiating nonenhancing glioblastoma from vasogenic edema. The identified threshold values may enhance glioblastoma characterization, improve preoperative differentiation from metastases, and support more precise, image-guided clinical management.

Indexed as

Brain EdemaBrain NeoplasmsDiffusion Magnetic Resonance ImagingGlioblastomaMagnetic Resonance ImagingAdultAgedAged, 80 and overContrast MediaDiagnosis, DifferentialFemaleHumansMaleMiddle AgedRetrospective StudiesContrast Media

Identifiers

PMID40968014
PMCPMC12633679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.