Evidence map›Paper›PMID 40967783›Full record

ArticleThe Journal of veterinary medical science2025

Assessment of motor deterioration in a cynomolgus macaque with neuronal ceroid lipofuscinosis type 2 disease using two behavioral analyses.

Yoshiko Munesue, Fumiko Ono, Naohide Ageyama, Ken-Ichi Yagami, Kazuhiro Ishii, Akira Tamaoka, Yasuhiro Yasutomi, Nobuhiro Shimozawa

Abstract read
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In one paragraph

Article in The Journal of veterinary medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yoshiko MunesueDivision of Clinical Medicine, Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Fumiko OnoDepartment of Veterinary Associated Science, Faculty of Veterinary Medicine, Okayama University of Science University, Okayama, Japan.
Naohide AgeyamaTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan.
Ken-Ichi YagamiLaboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Kazuhiro IshiiDivision of Clinical Medicine, Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Akira TamaokaDivision of Clinical Medicine, Department of Neurology, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
Yasuhiro YasutomiTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan.
Nobuhiro ShimozawaTsukuba Primate Research Center, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The classical late-infantile form of neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is a fatal lysosomal disorder characterized by progressive motor decline and premature death. A CLN2 cynomolgus macaque (Macaca fascicularis) model closely replicates the late-stage clinical and pathological features of human CLN2. To evaluate motor deterioration in this model, we conducted two behavioral assessments-the CLN2 Macaque Clinical Rating Scale and the Apple test-from the pre-onset stage in one macaque. Hypokinesia was observed as the first symptom at 22 months of age, followed by a marked decline in forelimb movement from 27 months. These simple, non-invasive, and cost-effective tests are valuable tools for monitoring disease progression and may facilitate the future clinical evaluation of therapeutic strategies for CLN2.

Indexed as

Behavior, AnimalMonkey DiseasesNeuronal Ceroid-LipofuscinosesAnimalsDisease Models, AnimalMacaca fascicularisbehavioral analysismotor skillneuronal ceroid lipofuscinosis

Identifiers

PMID40967783
PMCPMC12614823

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.