ArticleNeurologia medico-chirurgica2025
Evaluation of Cortical Microvascularization by Preoperative Maximum Intensity Projection Method in Moyamoya Disease Reflects the Increase of Pial Arteries on the Brain Surface.
Article in Neurologia medico-chirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microvascular proliferation on the cerebral surface is a hallmark feature of Moyamoya disease (MMD); however, studies on this phenomenon are limited. This study evaluated whether preoperative cortical microvascularization on partial maximum intensity projection (MIP) using three-dimensional rotational angiography corresponds to increased intraoperative pial arteries in MMD. We analyzed 24 hemispheres from 22 patients with MMD who underwent cerebral angiography and bypass surgery between October 2018 and July 2023. Control groups included patients with unruptured cerebral aneurysms (n = 15) and major cerebral artery occlusion (n = 10). Microvascular density (MVD) was calculated by measuring vascular area surgical videos. Cortical artery and periventricular anastomosis development were graded (0-2) using MIP images, with grade 2 indicating well-developed vessels. The mean age of the 22 patients was 41.3 ± 13.7 years, of which and 4 (18.1%) were male. Cortical microvascularization was observed in 12 hemispheres (50%). The mean MVD in MMD was 24.8 ± 5.9%, which was significantly higher than that in unruptured cerebral aneurysms (17.5 ± 2.4%; p < 0.001) and major cerebral artery occlusion (18.0 ± 2.2%; p < 0.001). MVD was significantly higher in hemispheres with cortical microvascularization (p = 0.014) and in those with well-developed thalamic arteries (THA; p < 0.001), however not in those with developed lenticulostriate or choroidal arteries. Our findings demonstrate that elevated intraoperative pial arteries in MMD correlate with cortical microvascularization and THA development in preoperative imaging. Further investigation into the vascular pathophysiology of MMD may refine diagnostic and therapeutic approaches.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.